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KMID : 0361019960390060993
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Korean Journal of Otolaryngology - Head and Neck Surgery
1996 Volume.39 No. 6 p.993 ~ p.999
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Expression of Cyclin DI Protein in Head and Neck Squamous Cell Carcinomas
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Abstract
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Cyclin DI is a cell cycle regulator essential for GI phase progression and a candidate protooncogene implicated in the pathogenesis of several human tumor types, including head and neck carcinomas And pRb acts as tumor suppressor and its function
seems
to be regulated by CDK(cyclin-dependent kinase)-cyclin complex. So immunohistochemical staining with monoclonal antibody against cyclin DI protein(BioGenex G124-326) and pRb(NCL-Rb) was done to investigate clinicopathologic meanings of cyclin DI
protein
and the relationship between cyclin DI protein and pRb in head and neck squamous cell carcinomas.
@ES The results were as follows:
@EN 1) The positive rate of cyclin DI was 25%(10/40) in head and neck squamous cell carcinomas. There was no significant difference in the positive rates of cyclin DI protein protein among subsites of head and neck regions.
2) The positive rates of cyclin DI were not affected by clinicopathologic parameters in head and neck squamous cell carcinomas.
3) The positive rates of cyclin DI were affected by positivity of Rb protein in head and neck squamous cell carcinoma.
In conclusion, cyclin DI protein can be a oncogenic potential but may not affect the clinicopathologic outcomes in head and neck squamous cell carcinomas. And the expression of pRb may stimulate the expression of cyclin DI protoin. (Korean J
Otolaryngo1
39 : 6, 1996)
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